Goal
The project aims to evaluate the impact of delayed administration of concordant antibiotic treatment on the 30-day mortality in hospitalised patients with bloodstream infection.
Lead
Myo Maung Maung Swe and Cherry Lim – Centre for Tropical Medicine and Global Health at the University of Oxford
What we did
We designed a target hypothetical trial with two treatment arms: (1) no delays and (2) at least one day of delay to concordant treatment. Data from the Mortality from Bacterial Infections Resistant to Antibiotics (MBIRA) study, conducted across eight African hospitals, were used to emulate the target trial.
Key learnings
We found no strong evidence of a difference in the risk of 30-day all-cause mortality between “no delay” and “at least 1-day delayed” in receiving concordant antibiotic treatment in the analysed patient population. While residual confounding cannot be ruled out and wide uncertainty intervals
Outputs
Funder
The Wellcome Trust